Preheat oven to 350 degrees Fahrenheit (175 degrees Celsius). Grease and flour a 9x5 inch loaf pan.
In a large bowl, whisk together flour, baking powder, baking soda, and salt.
In a separate bowl, cream together butter and sugar until light and fluffy.
Beat in eggs one at a time, then stir in vanilla extract. 5. In a small bowl, combine milk and lemon juice. Let stand for 5 minutes to thicken slightly.
Add the milk mixture and lemon zest to the butter mixture and mix until combined.
Gradually add the dry ingredients to the wet ingredients, mixing until just combined. Don't overmix.
Gently fold in the blueberries.
Pour the batter into the prepared loaf pan and bake for 50-60 minutes, or until a toothpick inserted into the center comes out clean.
Let the bread cool in the pan for 10 minutes before transferring it to a wire rack to cool completely.
Notes
If using frozen blueberries, do not thaw them before adding them to the batter.
You can add a lemon glaze to the top of the bread for extra lemony goodness. To make the glaze, whisk together 1 cup powdered sugar and 2-3 tablespoons of lemon juice.